It's been well studied in mice. Journal of Alzheimers Disease Volume 25 Number 2 Pages 323-335?Chuanhai Cao, Li Wang, Xiaoyang Lin, Malgorzata Mamcarz, Chi Zhang, Ge Bai, Jasson Nong, Sam Sussman, Gary Arendash (Handling Associate Editor: Jonathan Geiger)?Caffeine Synergizes with Another Coffee Component to Increase Plasma GCSF: Linkage to Cognitive Benefits in Alzheimer